Neuroprotective Effect of Cannabinoids in Neurodegenerative Diseases

ABSTRACT

Objectives: It is analysed the actual situation of the investigations related to cannabinoids substances, as well as their interaction with the organism, classification, therapeutics effects and their use in neurodegenerative diseases.
Methods: This study is based on the review of multiples scientific articles directly related with the cannabinoides substance and its synthetic derivates, with a special attention on the way the organism interacts and the effects the substances cause in it. Specifically, the study will get deep into the neuroantiinflammatory and analgesic effects of these substances, related with the neuroprotector effect in neurodegenerative diseases such as Alzheimer, Parkinson, Multiple Sclerosis and Amyotrophic Lateral Sclerosis.
Results: From thousands years, the Cannabis Sativa has been used by multiples cultures with different purposes such as joy, textile, analgesics etc. But is not till ends of the XX century when there are diverse scientific studies related with the Cannabis encouraged. The plant has 400 components, 60 of them belong to the cannabinoides group. The main ones are cannabinol, cannabidiol and tetrahidrocannabinol. With the discoverment of the cannabinoids substances, its derivates, and the receptors which interact with them, it is increased the therapeutic possibilities and remarking the neuroprotective effect which these substances contain.
Conclusions: It has been demostraded the huge potential of the cannabinoids as therapeutic substances apart from its analgesic and antiemetic uses, that is, neurodegenaritve diseases in which they can not only decrease its symptons but stop disease process. Another possible application could be in the oncologic area, being particularly intense the investigation’s activity realised the last 15 years.

Cannabis alters different cognitive functions 0031851072089 Amayim.com Company whatsapp

Cannabis alters different cognitive functions such as memory, perception, attention, comprehension, language, orientation or executive function. These alterations have been described both in situations of consumption, either for recreational or medicinal reasons, and in experimental situations, either in human studies or in experimental animals. These alterations can be acute, derived from intoxication, or sustained over time due to prolonged consumption.

DEUTSCHLAND

Berlin, das aufgrund seiner starken Wirtschafts- und Energiebeziehungen ein schwieriges Verhältnis zu Russland unterhält, verteidigt sich entschieden gegen eine militärische Aggression aus Moskau, entscheidet sich jedoch für den diplomatischen Weg, um Spannungen abzubauen. Der sozialdemokratische Bundeskanzler Olaf Scholz fordert von Russland "eindeutige Schritte" zur Deeskalation an der Grenze zur Ukraine. „Unmissverständliche Schritte Russlands zur Deeskalation sind sehr wichtig“, betonte die deutsche Bundeskanzlerin bei einer gemeinsamen Pressekonferenz mit Pedro Sánchez nach dem Treffen im Palacio de la Moncloa am Montag.

Scholz betont den Ernst der Lage, die eine „Gefahr für die Souveränität der Ukraine“ darstelle, für die er es für notwendig erachtet, „alles Mögliche zu tun“, um eine militärische Intervention zu vermeiden. „Die Unverletzlichkeit der Grenzen ist etwas, das wir respektieren müssen“, betont die Kanzlerin, die davor gewarnt hat, dass die klare Botschaft Deutschlands lautet, dass „jede Bedrohung der Integrität der Ukraine einen hohen Preis haben wird“.

cannabis


It comes from a plant called Cannabis sativa L, which is grown in temperate and tropical areas whose main mind-altering psychoactive chemical is delta-9-tetrahydrocannabinol (THC). This substance is found in a resin that is prepared from the stems and leaves of the female cannabis plant. In addition to THC, it contains more than 100 related compounds called cannabinoids. It is THC that is responsible for cannabis being a highly addictive drug.

 

It is usually consumed by inhalation, but also in infusions and even with food. One way or another, faster in the first, the THC passes into the bloodstream and from there to the brain. When consumption is weekly or daily, it can be considered an addiction.

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Hemp (Cannabis sativa), from which marijuana is extracted, could join the arsenal of weapons against COVID-19 that we are gradually making available. At least, that’s the conclusion of a study recently published in the Journal of Natural Products. However, if you are thinking of smoking some joints to keep the coronavirus away, we are sorry to tell you that it will not do any good. The theme does not work like that.

What the study authors, from Oregon State University, have seen is that, in vitro (under laboratory conditions), it can affect the ability of the virus to infect our cells.

It is important to emphasize that it has only been seen in the laboratory, because a handful of cells grown in a Petri dish (those round plates used in laboratories) is not the same as those same cells forming part of a living organism full. What works one way may not work another. However, the results have been so promising that these researchers believe they could be on the right track for the future development of an antiviral based on two ingredients derived from hemp, from which marijuana is extracted.

What type of drug is cannabis considered?

Cannabis is a drug that is extracted from the Cannabis sativa plant, with whose resin, leaves, stems and flowers are made the most widely used illegal drugs in Spain: hashish and marijuana. … Hash: made from the resin stored in the flowers of the female plant.

What does it feel like to smoke a joint?

Many experience a pleasant euphoria and a sense of relaxation. Other common effects, which can vary widely from person to person, include increased sensory perception (for example, brighter colors), laughter, altered perception of time, and increased appetite.

Vorteile von Marihuana für Ihren Körper und Ihr Gehirn

Schon mal was vom Runner High gehört? Es ist der Zustand der Euphorie, der beim Training auftritt. Die berühmten Endorphine, die beim Sport ausgeschüttet werden, erzeugen eine höhere Schmerzresistenz und ein Gefühl der Entspannung, aber die Euphorie und das Wohlbefinden kommen tatsächlich von einer anderen Gehirndroge: Anandamid, einem Endocannabinoid. Um uns zu verstehen, Marihuana, das Ihr eigenes Gehirn herstellt.
Wie viele andere Medikamente enthält Marihuana Substanzen, die unseren natürlichen Neurotransmittern ähneln. In diesem Fall ist es Tetrahydrocannabinol oder THC, das auf unser Gehirn die gleiche Wirkung hat wie Anandamid: Kurzfristig ein Wohlgefühl und eine Verstärkung der Lustgefühle, eine Erhöhung der Schmerzschwelle, aber auch eine gewisse Störung der Gedächtnisbildung und motorische Funktionen.
Darüber hinaus enthält Marihuana eine andere Substanz namens Cannabidiol oder CBD, die, wenn sie das Gehirn erreicht, die Spiegel eines anderen endogenen Neurotransmitters namens 2-AG erhöht, der für die Regulierung des Appetits (daher den Hunger, den die Gelenke erzeugen) verantwortlich ist, und noch viel wichtiger , das Immunsystem und die Schmerzregulation. THC ist psychotrop und es ist der Teil von Cannabis, der dir die “erholsamen” Wirkungen verleiht. CBD erzeugt diese Wirkungen nicht, aber es beeinflusst die Gehirnfunktion und die allgemeine Gesundheit in vielen Fällen positiv.
Wir finden also eine Pflanze, die Wirkstoffe enthält, die chemische Schalter im Gehirn ein- und ausschalten, indem sie unsere eigenen Neurotransmitter nachahmen. Die schlechte Nachricht ist, dass diese Pflanze illegal ist. Die gute Nachricht ist, dass die Zeit, in der sich seine Verwendung für die Behandlung vieler Krankheiten normalisiert, immer näher rückt.

Behandlung von Epilepsie


Cannabidiol oder CBD, die nicht-psychotrope Komponente von Marihuana, kann laut einer von The Lancet veröffentlichten Studie helfen, epileptische Anfälle bei Kindern und Jugendlichen zu kontrollieren. Dies stimmt auch mit Beobachtungen von Patienten überein, die Cannabis allein konsumierten, um die Symptome zu verbessern, und mit weniger Nebenwirkungen.

Es kann die Entwicklung von Krebs verlangsamen und die Auswirkungen einer Chemotherapie lindern
Die gleiche CBD-Komponente kann laut der Studie der San Francisco University die Entwicklung von Brustkrebs verlangsamen. Andere Studien mit Mäusen haben gezeigt, dass THC auch das Wachstum von Tumoren verlangsamt, und eine neuere Studie, die CBD und THC kombiniert, ergab, dass die Zugabe zu einer Strahlentherapie eine wirksamere Behandlung für die Entwicklung von Gliomen, dem häufigsten Hirntumor, war. Diese Ergebnisse wurden jedoch noch nicht beim Menschen repliziert.

Krebspatienten, die mit einer Chemotherapie behandelt werden, leiden unter Übelkeit, Erbrechen und Appetitlosigkeit. Mehrere Studien haben gezeigt, dass das Rauchen von Marihuana oder die Verwendung von THC-basierten Medikamenten diese Symptome lindern können.

LES SUBSTANCES FUMÉES RENDENT LES CHOSES ENCORE PLUS

Après avoir inhalé la fumée chaude, le passage du pharynx aux bronchioles dans les poumons est chaud, sec et irrité ; Cela peut même commencer à faire mal. À ce stade, il serait préférable de ne pas aggraver la situation. Mais c’est exactement ce que nous faisons, puisque nous fumons de l’herbe. Les substances contenues dans la fumée, y compris les cannabinoïdes aromatiques et les terpènes, ainsi que les toxines de la fumée elle-même, irriteront davantage votre gorge déjà irritée.

POURQUOI FUMER DE LA MARIJUANA FAIT-IL TOUSSER ?

Après une bonne fumée, votre gorge est non seulement sèche et irritée, mais vous avez aussi une vilaine toux. Et une fois que vous commencez à tousser, cela aggrave votre gorge, vous fait tousser encore plus, ce qui signifie plus d’irritation et plus de toux… Eh bien, vous voyez l’idée.

Comment soigner un mal de gorge après avoir fumé du cannabis

L’un des inconvénients les plus courants de la consommation de marijuana est le mal de gorge. Nous vous expliquons pourquoi cela se produit et nous vous proposons quelques remèdes pour y remédier.
Fumer de la marijuana a des effets merveilleux. Mais cela peut également entraîner des effets secondaires moins agréables, tels que la sécheresse buccale redoutée (lorsque votre bouche et votre gorge deviennent sèches et irritées après avoir fumé).

Comme il est assez fréquent de souffrir de maux de gorge après avoir fumé de la marijuana, nous avons analysé ses causes et comment vous pouvez soulager un mal de gorge.


Rim’K – Papel ft. Morad (Video Oficial)

Neuer Song von Rim’s und Morad – Song zum ruhig anhören beim Rauchen 🙂

Lila Marihuana

Diese Art von Marihuana enthält sehr hohe und ausgewogene Mengen an THC und CBD. Daher gibt es Ihnen ein sofortiges High, gefolgt von ausgezeichneter Entspannung.

Welche Behandlungen gibt es für Marihuanakonsumstörungen?

Derzeit gibt es keine Medikamente zur Behandlung von Marihuanakonsumstörungen, aber unterstützende Methoden zur Verhaltensänderung haben sich als wirksam erwiesen. Beispiele für diese Art der Hilfeleistung sind Therapie- und Motivationsanreize (Belohnung von Patienten, die auf Medikamente verzichten). Es ist möglich, dass im Laufe der Forschung neue Medikamente entdeckt werden, die Entzugssymptome lindern, die Wirkung von Marihuana blockieren und Rückfälle verhindern.

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